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Target
Pepsin A
Ligand
BDBM50432601
Substrate
n/a
Meas. Tech.
ChEMBL_950727 (CHEMBL2353188)
IC50
>200000±n/a nM
Citation
 Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem 56:3980-95 (2013) [PubMed]  Article 
Target
Name:
Pepsin A
Synonyms:
PEPA_PIG | PGA | Pepsin | Pepsin A precursor
Type:
Enzyme
Mol. Mass.:
41232.87
Organism:
Porcine
Description:
n/a
Residue:
385
Sequence:
MKWLLLLSLVVLSECLVKVPLVRKKSLRQNLIKNGKLKDFLKTHKHNPASKYFPEAAALIGDEPLENYLDTEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSVYCSSLACSDHNQFNPDDSSTFEATSQELSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISASGATPVFDNLWDQGLVSQDLFSVYLSSNDDSGSVVLLGGIDSSYYTGSLNWVPVSVEGYWQITLDSITMDGETIACSGGCQAIVDTGTSLLTGPTSAIANIQSDIGASENSDGEMVISCSSIDSLPDIVFTINGVQYPLSPSAYILQDDDSCTSGFEGMDVPTSSGELWILGDVFIRQYYTVFDRANNKVGLAPVA
  
Inhibitor
Name:
BDBM50432601
Synonyms:
CHEMBL2347208 | US9296734, 102
Type:
Small organic molecule
Emp. Form.:
C19H15F4N5O2
Mol. Mass.:
421.3483
SMILES:
C[C@]1(C[C@H](OC(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F |r,c:6|
Structure:
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