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Target
Transcriptional activator Myb
Ligand
BDBM50433427
Substrate
n/a
Meas. Tech.
ChEMBL_958516 (CHEMBL2383288)
IC50
4680±n/a nM
Citation
 Schomburg, C; Schuehly, W; Da Costa, FB; Klempnauer, KH; Schmidt, TJ Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships. Eur J Med Chem 63:313-20 (2013) [PubMed]  Article 
Target
Name:
Transcriptional activator Myb
Synonyms:
MYB | MYB_CHICK | Proto-oncogene c-Myb
Type:
PROTEIN
Mol. Mass.:
72474.34
Organism:
Gallus gallus
Description:
ChEMBL_107588
Residue:
641
Sequence:
MARRPRHSIYSSDDDEEDVEMYDHDYDGLLPKAGKRHLGKTRWTREEDEKLKKLVEQNGTEDWKVIASFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKAGLPSATTGFQKSSHLMAFAHNPPAGPLPGAGQAPLGSDYPYYHIAEPQNVPGQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTANYPGWHSTTVADNTRTSGDNAPVSCLGEHHHCTPSPPVDHGCLPEESASPARCMIVHQSNILDNVKNLLEFAETLQLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHRDQPFKTQKENHVFRTPAIKRSILESSPRTPTPFKNALAAQEIKYGPLKMLPQTPTHLVEDLQDVIKQESEESAIVAGLHESGPPLLKKIKQEVESPTDKAGNFFCSNHWEGENLNTQLFTHASTMEDVPNLLTSSILKMPVSEEEGSFHKAFAVPRNRPLASPMQHLNNAWESASCGKTEDQMALTDQARKYMAAFPTRTLVM
  
Inhibitor
Name:
BDBM50433427
Synonyms:
CHEMBL2380781
Type:
Small organic molecule
Emp. Form.:
C22H28O10
Mol. Mass.:
452.4517
SMILES:
COC(=O)C1=C/[C@@H](O)C\C(CO)=C/[C@H]2OC(=O)C(=C)[C@@H]2[C@H](OC(=O)C(C)C)[C@@H]\1OC(C)=O |r,c:11,t:4|
Structure:
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