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Target
Testis-specific serine/threonine-protein kinase 2
Ligand
BDBM50433476
Substrate
n/a
Meas. Tech.
ChEMBL_959509 (CHEMBL2384676)
IC50
8900±n/a nM
Citation
 Huang, X; Cheng, CC; Fischmann, TO; Duca, JS; Richards, M; Tadikonda, PK; Reddy, PA; Zhao, L; Siddiqui, MA; Parry, D; Davis, N; Seghezzi, W; Wiswell, D; Shipps, GW Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorg Med Chem Lett 23:2590-4 (2013) [PubMed]  Article 
Target
Name:
Testis-specific serine/threonine-protein kinase 2
Synonyms:
DGSG | SPOGA2 | STK22B | TSSK2 | TSSK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
40954.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459845
Residue:
358
Sequence:
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
  
Inhibitor
Name:
BDBM50433476
Synonyms:
CHEMBL2381116
Type:
Small organic molecule
Emp. Form.:
C22H22N6O3S
Mol. Mass.:
450.513
SMILES:
COc1ccc2CN(C(=O)c2c1)c1nc(cs1)C(=O)Nc1cnccc1N1CCNCC1
Structure:
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