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Target
Nuclear receptor subfamily 1 group D member 1
Ligand
BDBM50434044
Substrate
n/a
Meas. Tech.
ChEMBL_958222 (CHEMBL2384565)
EC50
630±n/a nM
Citation
 Trump, RP; Bresciani, S; Cooper, AW; Tellam, JP; Wojno, J; Blaikley, J; Orband-Miller, LA; Kashatus, JA; Boudjelal, M; Dawson, HC; Loudon, A; Ray, D; Grant, D; Farrow, SN; Willson, TM; Tomkinson, NC Optimized chemical probes for REV-ERBa. J Med Chem 56:4729-37 (2013) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group D member 1
Synonyms:
EAR-1 | EAR1 | HREV | NR1D1 | NR1D1_HUMAN | Rev-erbA-alpha | THRAL | V-erbA-related protein 1
Type:
PROTEIN
Mol. Mass.:
66822.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_958222
Residue:
614
Sequence:
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
  
Inhibitor
Name:
BDBM50434044
Synonyms:
CHEMBL2381194
Type:
Small organic molecule
Emp. Form.:
C19H15F2N3S
Mol. Mass.:
355.404
SMILES:
Fc1ccc(F)c(CN(Cc2ccc(s2)C#N)Cc2cccnc2)c1
Structure:
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