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Target
Protein mono-ADP-ribosyltransferase PARP6
Ligand
BDBM50434127
Substrate
n/a
Meas. Tech.
ChEMBL_958906 (CHEMBL2382484)
IC50
>10000±n/a nM
Citation
 Larsson, EA; Jansson, A; Ng, FM; Then, SW; Panicker, R; Liu, B; Sangthongpitag, K; Pendharkar, V; Tai, SJ; Hill, J; Dan, C; Ho, SY; Cheong, WW; Poulsen, A; Blanchard, S; Lin, GR; Alam, J; Keller, TH; Nordlund, P Fragment-based ligand design of novel potent inhibitors of tankyrases. J Med Chem 56:4497-508 (2013) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP6
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 17 | ARTD17 | PARP-6 | PARP6 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6
Type:
PROTEIN
Mol. Mass.:
71130.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107589
Residue:
630
Sequence:
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
  
Inhibitor
Name:
BDBM50434127
Synonyms:
CHEMBL2381633
Type:
Small organic molecule
Emp. Form.:
C16H12FNO
Mol. Mass.:
253.271
SMILES:
Cc1cc(=O)[nH]c2cc(ccc12)-c1ccccc1F
Structure:
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