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Target
Protein mono-ADP-ribosyltransferase PARP6
Ligand
BDBM50434157
Substrate
n/a
Meas. Tech.
ChEMBL_959426 (CHEMBL2384338)
IC50
>10000±n/a nM
Citation
 Bregman, H; Chakka, N; Guzman-Perez, A; Gunaydin, H; Gu, Y; Huang, X; Berry, V; Liu, J; Teffera, Y; Huang, L; Egge, B; Mullady, EL; Schneider, S; Andrews, PS; Mishra, A; Newcomb, J; Serafino, R; Strathdee, CA; Turci, SM; Wilson, C; DiMauro, EF Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors. J Med Chem 56:4320-42 (2013) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP6
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 17 | ARTD17 | PARP-6 | PARP6 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6
Type:
PROTEIN
Mol. Mass.:
71130.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107589
Residue:
630
Sequence:
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
  
Inhibitor
Name:
BDBM50434157
Synonyms:
CHEMBL2381958 | US9340549, 78
Type:
Small organic molecule
Emp. Form.:
C27H23N3O3
Mol. Mass.:
437.4898
SMILES:
CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |r|
Structure:
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