Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM50434272
Substrate
n/a
Meas. Tech.
ChEMBL_961297 (CHEMBL2390473)
EC50
12000±n/a nM
Citation
 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators. ACS Med Chem Lett 4:475-80 (2013) [PubMed]  Article 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM50434272
Synonyms:
CHEMBL1242297
Type:
Small organic molecule
Emp. Form.:
C23H16ClN3O6S
Mol. Mass.:
497.908
SMILES:
Cc1cc(-c2ccc(\C=C3/S\C(NC3=O)=N/c3ccc(Cl)c(c3)C(O)=O)o2)c(cc1C)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: