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Target
Caspase-3
Ligand
BDBM50435409
Substrate
n/a
Meas. Tech.
ChEMBL_965518 (CHEMBL2395466)
IC50
438±n/a nM
Citation
 Liu, D; Tian, Z; Yan, Z; Wu, L; Ma, Y; Wang, Q; Liu, W; Zhou, H; Yang, C Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors. Bioorg Med Chem 21:2960-7 (2013) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM50435409
Synonyms:
CHEMBL2391772
Type:
Small organic molecule
Emp. Form.:
C14H9FN2O2S
Mol. Mass.:
288.297
SMILES:
Fc1cccc(NC(=O)n2sc3ccccc3c2=O)c1
Structure:
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