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Target
Macrophage inflammatory protein-1 alpha receptor
Ligand
BDBM50435676
Substrate
n/a
Meas. Tech.
ChEMBL_964985 (CHEMBL2396018)
IC50
79±n/a nM
Citation
 Hossain, N; Ivanova, S; Bergare, J; Mensonides-Harsema, M; Cooper, ME Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists. Bioorg Med Chem Lett 23:3500-4 (2013) [PubMed]  Article 
Target
Name:
Macrophage inflammatory protein-1 alpha receptor
Synonyms:
C-C chemokine receptor type 1
Type:
PROTEIN
Mol. Mass.:
40846.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1281523
Residue:
355
Sequence:
MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFVFIIGVVGNILVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWALAILASIPALCFFKAQWEFTHHTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPNEKKAKAVRLIFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQSKQLDLAIQVTEVIAYTHCCVNPIIYVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVDQLERTSSLTPSTGEHELSGGF
  
Inhibitor
Name:
BDBM50435676
Synonyms:
CHEMBL2391938
Type:
Small organic molecule
Emp. Form.:
C26H31ClN2O5
Mol. Mass.:
486.988
SMILES:
COc1ccc(C(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(Cc4cc(Cl)ccc4O3)CC2)c1 |r|
Structure:
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