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Target
Macrophage inflammatory protein-1 alpha receptor
Ligand
BDBM50435684
Substrate
n/a
Meas. Tech.
ChEMBL_964985 (CHEMBL2396018)
IC50
890±n/a nM
Citation
 Hossain, N; Ivanova, S; Bergare, J; Mensonides-Harsema, M; Cooper, ME Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists. Bioorg Med Chem Lett 23:3500-4 (2013) [PubMed]  Article 
Target
Name:
Macrophage inflammatory protein-1 alpha receptor
Synonyms:
C-C chemokine receptor type 1
Type:
PROTEIN
Mol. Mass.:
40846.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1281523
Residue:
355
Sequence:
MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFVFIIGVVGNILVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWALAILASIPALCFFKAQWEFTHHTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPNEKKAKAVRLIFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQSKQLDLAIQVTEVIAYTHCCVNPIIYVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVDQLERTSSLTPSTGEHELSGGF
  
Inhibitor
Name:
BDBM50435684
Synonyms:
CHEMBL2391794
Type:
Small organic molecule
Emp. Form.:
C23H27FN2O5
Mol. Mass.:
430.4693
SMILES:
CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(Cc3cc(F)ccc3O2)CC1 |r|
Structure:
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