Reaction Details
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Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50150389
Substrate
n/a
Meas. Tech.
ChEMBL_964080 (CHEMBL2394433)
IC50
60±n/a nM
Citation
Yang, D; Arifhodzic, L; Ganellin, CR; Jenkinson, DH Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels. Eur J Med Chem 63:907-23 (2013) [PubMed] Article More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
K3 | KCNN3 | KCNN3_HUMAN | Small conductance calcium-activated potassium channel protein 3 | Small conductance calcium-activated potassium channel protein 3 (KCa2.3)
Type:
Protein
Mol. Mass.:
82053.75
Organism:
Homo sapiens (Human)
Description:
Q9UGI6
Residue:
731
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
Inhibitor
Name:
BDBM50150389
Synonyms:
17,23-diazonia-2,9-diazahexacyclo[21.6.2.24,7.210,17.011,16.024,29]pentatriaconta-1(29),4,6,10(33),11,13,15,17(32),23,25,27,30,34-tridecaene | CHEMBL360621
Type:
Small organic molecule
Emp. Form.:
C31H32N4
Mol. Mass.:
460.6115
SMILES:
C1CCn2cc[c+](NCc3ccc(CN[c+]4ccn(CC1)c1ccccc41)cc3)c1ccccc21
Structure:
