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Target
Bcl-2-like protein 1
Ligand
BDBM50436669
Substrate
n/a
Meas. Tech.
ChEMBL_967619 (CHEMBL2399239)
IC50
150±n/a nM
Citation
 Sleebs, BE; Kersten, WJ; Kulasegaram, S; Nikolakopoulos, G; Hatzis, E; Moss, RM; Parisot, JP; Yang, H; Czabotar, PE; Fairlie, WD; Lee, EF; Adams, JM; Chen, L; van Delft, MF; Lowes, KN; Wei, A; Huang, DC; Colman, PM; Street, IP; Baell, JB; Watson, K; Lessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem 56:5514-40 (2014) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50436669
Synonyms:
CHEMBL2398289
Type:
Small organic molecule
Emp. Form.:
C33H31FN4O7S2
Mol. Mass.:
678.75
SMILES:
[O-][N+](=O)c1cc(ccc1N[C@@H](CSc1ccccc1)CC(=O)N1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1)-c1ccc(F)cc1 |r|
Structure:
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