Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50436683
Substrate
n/a
Meas. Tech.
ChEMBL_967970 (CHEMBL2401074)
Ki
0.970000±n/a nM
Citation
 Zhao, Y; Yu, S; Sun, W; Liu, L; Lu, J; McEachern, D; Shargary, S; Bernard, D; Li, X; Zhao, T; Zou, P; Sun, D; Wang, S A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem 56:5553-61 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50436683
Synonyms:
CHEMBL2398478
Type:
Small organic molecule
Emp. Form.:
C28H32Cl2FN3O3
Mol. Mass.:
548.476
SMILES:
CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1C[C@](C)(O)C1 |r,wU:33.37,17.19,8.8,31.34,5.4,wD:33.38,7.31,(28.66,-31.03,;27.45,-30.07,;27.69,-28.55,;28.93,-29.66,;26.02,-30.63,;24.82,-29.66,;24.89,-28.12,;23.45,-27.58,;22.49,-28.78,;21.15,-28.01,;19.82,-28.78,;18.48,-28.02,;18.47,-26.46,;19.81,-25.69,;19.81,-24.15,;21.15,-26.46,;21.14,-24.91,;23.33,-30.07,;24.24,-31.33,;25.78,-31.33,;23.33,-32.58,;21.86,-32.1,;20.52,-32.87,;19.19,-32.1,;17.86,-32.87,;19.19,-30.56,;20.52,-29.79,;21.86,-30.55,;23.46,-26.04,;22.13,-25.26,;24.79,-25.27,;26.33,-25.26,;27.42,-24.18,;28.5,-25.26,;29.83,-24.48,;29.84,-26.02,;27.43,-26.36,)|
Structure:
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