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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50436717
Substrate
n/a
Meas. Tech.
ChEMBL_966862 (CHEMBL2401006)
IC50
11000±n/a nM
Citation
 Hu, X; Compton, JR; Abdulhameed, MD; Marchand, CL; Robertson, KL; Leary, DH; Jadhav, A; Hershfield, JR; Wallqvist, A; Friedlander, AM; Legler, PM 3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening. J Med Chem 56:5275-87 (2014) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
fabI
Type:
PROTEIN
Mol. Mass.:
27804.42
Organism:
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Description:
Q5NGQ3
Residue:
260
Sequence:
MGFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL
  
Inhibitor
Name:
BDBM50436717
Synonyms:
CHEMBL2398663
Type:
Small organic molecule
Emp. Form.:
C13H8FNO2
Mol. Mass.:
229.2065
SMILES:
Oc1ccccc1Oc1ccc(cc1F)C#N
Structure:
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