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Target
Isocitrate lyase
Ligand
BDBM50402850
Substrate
n/a
Meas. Tech.
ChEMBL_972063 (CHEMBL2406167)
IC50
10360±n/a nM
Citation
 Ahn, CH; Won, TH; Kim, H; Shin, J; Oh, KB Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp. Bioorg Med Chem Lett 23:4099-101 (2013) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_CANAX | ICL1
Type:
PROTEIN
Mol. Mass.:
61398.95
Organism:
Candida albicans
Description:
ChEMBL_972063
Residue:
550
Sequence:
MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQADKLFKLLETHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGITAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIESEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSNQYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTEDQFKESKAKA
  
Inhibitor
Name:
BDBM50402850
Synonyms:
CHEMBL2204157
Type:
Small organic molecule
Emp. Form.:
C25H12Br6O7
Mol. Mass.:
903.783
SMILES:
[#6]-[#8]-[#6](=O)-[#6]1=[#6](-[#6](=O)-[#8]\[#6]-1=[#6](/c1cc(Br)c(-[#8])c(Br)c1)-c1cc(Br)c(-[#8])c(Br)c1)-c1cc(Br)c(-[#8])c(Br)c1 |t:4|
Structure:
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