Reaction Details Report a problem with these data
Target
Replication protein A 70 kDa DNA-binding subunit
Ligand
BDBM50437278
Substrate
n/a
Meas. Tech.
ChEMBL_972453 (CHEMBL2412823)
Kd
>250000±n/a nM
Citation
 Patrone, JD; Kennedy, JP; Frank, AO; Feldkamp, MD; Vangamudi, B; Pelz, NF; Rossanese, OW; Waterson, AG; Chazin, WJ; Fesik, SW Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med Chem Lett 4:601-605 (2013) [PubMed]  Article 
Target
Name:
Replication protein A 70 kDa DNA-binding subunit
Synonyms:
REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:
Enzyme
Mol. Mass.:
68139.43
Organism:
Homo sapiens (Human)
Description:
P27694
Residue:
616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
  
Inhibitor
Name:
BDBM50437278
Synonyms:
CHEMBL2407453
Type:
Small organic molecule
Emp. Form.:
C17H10FN3O2S2
Mol. Mass.:
371.409
SMILES:
OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1ccc(F)cc1
Structure:
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