Reaction Details Report a problem with these data
Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50438468
Substrate
n/a
Meas. Tech.
ChEMBL_976205 (CHEMBL2415854)
Ki
>10000±n/a nM
Citation
 Clinch, K; Crump, DR; Evans, GB; Hazleton, KZ; Mason, JM; Schramm, VL; Tyler, PC Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorg Med Chem 21:5629-46 (2013) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50438468
Synonyms:
CHEMBL2414628
Type:
Small organic molecule
Emp. Form.:
C11H17N4O7P
Mol. Mass.:
348.249
SMILES:
OC[C@@H](NCc1c[nH]c2c1nc[nH]c2=O)[C@H](O)COP(O)(O)=O |r|
Structure:
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