Reaction Details
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Cyclin-dependent kinase 9
Ligand
BDBM50434821
Substrate
n/a
Meas. Tech.
ChEMBL_979732 (CHEMBL2421777)
Ki
111±n/a nM
Citation
Liang, J; Tsui, V; Van Abbema, A; Bao, L; Barrett, K; Beresini, M; Berezhkovskiy, L; Blair, WS; Chang, C; Driscoll, J; Eigenbrot, C; Ghilardi, N; Gibbons, P; Halladay, J; Johnson, A; Kohli, PB; Lai, Y; Liimatta, M; Mantik, P; Menghrajani, K; Murray, J; Sambrone, A; Xiao, Y; Shia, S; Shin, Y; Smith, J; Sohn, S; Stanley, M; Ultsch, M; Zhang, B; Wu, LC; Magnuson, S Lead identification of novel and selective TYK2 inhibitors. Eur J Med Chem 67:175-87 (2013) [PubMed] Article More Info.:
Target
Name:
Cyclin-dependent kinase 9
Synonyms:
C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
42789.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
Inhibitor
Name:
BDBM50434821
Synonyms:
CHEMBL2387224
Type:
Small organic molecule
Emp. Form.:
C16H13Cl2N3O2
Mol. Mass.:
350.199
SMILES:
Clc1cccc(Cl)c1C(=O)Nc1ccnc(NC(=O)C2CC2)c1
Structure:
