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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM50439057
Substrate
n/a
Meas. Tech.
ChEMBL_980054 (CHEMBL2423310)
IC50
2440±n/a nM
Citation
 Emmerich, J; Hu, Q; Hanke, N; Hartmann, RW Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type. J Med Chem 56:6022-32 (2013) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_RAT | Cyp11b-1 | Cyp11b1 | Cytochrome P450 11B | Cytochrome P450 11B1
Type:
PROTEIN
Mol. Mass.:
57478.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1475489
Residue:
499
Sequence:
MALRVTADVWLARPWQCLHRTRALGTTAKVAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPHRMPLEPWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAIQSFVPFVDVVARDFVENLKKRMLENVHGSMSINIQSNMFNYTMEASHFVISGERLGLTGHDLKPESVTFTHALHSMFKSTTQLMFLPKSLTRWTSTRVWKEHFDSWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIVANPQKAMSDLPLLRAALKETLRLYPVGSFVERIVHSDLVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPSSSPFLTFRPVS
  
Inhibitor
Name:
BDBM50439057
Synonyms:
CHEMBL2417553
Type:
Small organic molecule
Emp. Form.:
C18H16N2
Mol. Mass.:
260.333
SMILES:
Cc1cncc(Cc2ccc(nc2)-c2ccccc2)c1
Structure:
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