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Target
Cell division protein FtsZ
Ligand
BDBM50439496
Substrate
n/a
Meas. Tech.
ChEMBL_979349 (CHEMBL2423040)
IC50
38000±n/a nM
Citation
 Keffer, JL; Huecas, S; Hammill, JT; Wipf, P; Andreu, JM; Bewley, CA Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Bioorg Med Chem 21:5673-8 (2013) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50439496
Synonyms:
CHEMBL2418096 | US9169182, J23
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2O4
Mol. Mass.:
369.239
SMILES:
COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Structure:
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