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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50126410
Substrate
n/a
Meas. Tech.
ChEMBL_983771 (CHEMBL2428110)
IC50
72±n/a nM
Citation
 Kaur, M; Singh, M; Silakari, O Inhibitors of switch kinase 'spleen tyrosine kinase' in inflammation and immune-mediated disorders: a review. Eur J Med Chem 67:434-46 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50126410
Synonyms:
CHEMBL30548 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin-5-yl]-N*1*-methyl-propane-1,3-diamine | N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5-yl)-N1-methylpropane-1,3-diamine
Type:
Small organic molecule
Emp. Form.:
C20H25N5
Mol. Mass.:
335.446
SMILES:
CN(C)c1ccc(cc1)-c1cc2ncccc2c(n1)N(C)CCCN
Structure:
Search PDB for entries with ligand similarity: