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Target
Peptidyl-prolyl cis-trans isomerase B
Ligand
BDBM50440293
Substrate
n/a
Meas. Tech.
ChEMBL_982569 (CHEMBL2428072)
Ki
35±n/a nM
Citation
 Malesevic, M; Gutknecht, D; Prell, E; Klein, C; Schumann, M; Nowak, RA; Simon, JC; Schiene-Fischer, C; Saalbach, A Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147. J Med Chem 56:7302-11 (2013) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase B
Synonyms:
CYP-S1 | CYPB | Cyclophilin B | Cyclophilin B (CypB) | PPIB | PPIB_HUMAN | PPIase | Peptidyl-prolyl cis-trans isomerase B | Rotamase | S-cyclophilin | SCYLP
Type:
Protein
Mol. Mass.:
23751.82
Organism:
Homo sapiens (Human)
Description:
P23284
Residue:
216
Sequence:
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
  
Inhibitor
Name:
BDBM50440293
Synonyms:
CHEMBL2424822
Type:
Small organic molecule
Emp. Form.:
C67H111N13O14
Mol. Mass.:
1322.6769
SMILES:
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)Cc2nc3ccc(cc3[nH]2)C(O)=O)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |r|
Structure:
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