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Target
Proteinase-activated receptor 2
Ligand
BDBM50440869
Substrate
n/a
Meas. Tech.
ChEMBL_984146
IC50
1100±n/a nM
Citation
 Yau, MK; Liu, L; Fairlie, DP Toward drugs for protease-activated receptor 2 (PAR2). J Med Chem 56:7477-97 (2013) [PubMed]  Article  BDB Entry
Target
Name:
Proteinase-activated receptor 2
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50440869
Synonyms:
CHEMBL2431727
Type:
Small organic molecule
Emp. Form.:
C51H56Cl2N8O4
Mol. Mass.:
915.948
SMILES:
NCCCC[C@H](NC(=O)CNC(=O)Nc1ccc2n(Cc3c(Cl)cccc3Cl)cc(CN3CCCC3)c2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC(c1ccccc1)c1ccccc1 |r|
Structure:
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