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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50441890
Substrate
n/a
Meas. Tech.
ChEMBL_987264 (CHEMBL2437893)
Ki
959±n/a nM
Citation
 Zhang, Z; Liang, X; Li, X; Song, T; Chen, Q; Sheng, H Design and application of a rigid quinazolone scaffold based on two-face Bima-helix mimicking. Eur J Med Chem 69:711-8 (2013) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50441890
Synonyms:
CHEMBL2436890
Type:
Small organic molecule
Emp. Form.:
C21H16N2O4
Mol. Mass.:
360.3627
SMILES:
Oc1cc2c(nc(-c3ccccc3)n(Cc3ccccc3)c2=O)c(O)c1O
Structure:
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