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Target
DNA nucleotidylexotransferase
Ligand
BDBM50442209
Substrate
n/a
Meas. Tech.
ChEMBL_991705 (CHEMBL2445053)
Ki
1500±n/a nM
Citation
 Costi, R; Crucitti, GC; Pescatori, L; Messore, A; Scipione, L; Tortorella, S; Amoroso, A; Crespan, E; Campiglia, P; Maresca, B; Porta, A; Granata, I; Novellino, E; Gouge, J; Delarue, M; Maga, G; Di Santo, R New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. J Med Chem 56:7431-41 (2013) [PubMed]  Article 
Target
Name:
DNA nucleotidylexotransferase
Synonyms:
DNA nucleotidylexotransferase | DNTT | TDT | TDT_HUMAN | Terminal addition enzyme | Terminal deoxynucleotidyltransferase | Terminal transferase
Type:
PROTEIN
Mol. Mass.:
58545.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210231
Residue:
509
Sequence:
MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMTGKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCEFRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLVSCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQLLQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSSWQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKTKRIFLKAESEEEIFAHLGLDYIEPWERNA
  
Inhibitor
Name:
BDBM50442209
Synonyms:
CHEMBL2441980
Type:
Small organic molecule
Emp. Form.:
C20H16N2O5
Mol. Mass.:
364.3514
SMILES:
CCOC(=O)C(=O)CC(=O)C=Cc1cc(c[nH]1)C(=O)c1ccc(cc1)C#N |w:11.11|
Structure:
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