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Target
Histamine receptor H3
Ligand
BDBM50442632
Substrate
n/a
Meas. Tech.
ChEMBL_990753 (CHEMBL2443820)
Ki
0.970000±n/a nM
Citation
 Gao, Z; Hurst, WJ; Czechtizky, W; Francon, D; Griebel, G; Nagorny, R; Pichat, P; Schwink, L; Stengelin, S; Hendrix, JA; George, PG Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders. Bioorg Med Chem Lett 23:6141-5 (2013) [PubMed]  Article 
Target
Name:
Histamine receptor H3
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
48611.84
Organism:
Macaca mulatta (Rhesus macaque)
Description:
Q865E1
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM50442632
Synonyms:
CHEMBL2441636
Type:
Small organic molecule
Emp. Form.:
C22H33N3O2
Mol. Mass.:
371.5163
SMILES:
C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CCOCC2)c(C)c1 |r|
Structure:
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