Reaction Details Report a problem with these data
Target
Replication protein A 70 kDa DNA-binding subunit
Ligand
BDBM50443305
Substrate
n/a
Meas. Tech.
ChEMBL_1274586 (CHEMBL3091186)
Kd
710000±n/a nM
Citation
 Frank, AO; Feldkamp, MD; Kennedy, JP; Waterson, AG; Pelz, NF; Patrone, JD; Vangamudi, B; Camper, DV; Rossanese, OW; Chazin, WJ; Fesik, SW Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J Med Chem 56:9242-50 (2013) [PubMed]  Article 
Target
Name:
Replication protein A 70 kDa DNA-binding subunit
Synonyms:
REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:
Enzyme
Mol. Mass.:
68139.43
Organism:
Homo sapiens (Human)
Description:
P27694
Residue:
616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
  
Inhibitor
Name:
BDBM50443305
Synonyms:
CHEMBL3088226
Type:
Small organic molecule
Emp. Form.:
C11H6ClFO3
Mol. Mass.:
240.615
SMILES:
OC(=O)c1ccc(o1)-c1ccc(F)c(Cl)c1
Structure:
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