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Target
Neuropeptide S receptor
Ligand
BDBM89034
Substrate
n/a
Meas. Tech.
ChEMBL_1276605 (CHEMBL3088890)
IC50
30±n/a nM
Citation
 Patnaik, S; Marugan, JJ; Liu, K; Zheng, W; Southall, N; Dehdashti, SJ; Thorsell, A; Heilig, M; Bell, L; Zook, M; Eskay, B; Brimacombe, KR; Austin, CP Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. J Med Chem 56:9045-56 (2013) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14
Type:
PROTEIN
Mol. Mass.:
42692.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1276607
Residue:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM89034
Synonyms:
(1,2-dimethyl-3-imidazo[1,2-a]pyridin-4-iumyl)-diphenyl-sulfanylidenephosphorane;methyl sulfate | (1,2-dimethylimidazo[1,2-a]pyridin-4-ium-3-yl)-diphenyl-sulfanylidene--phosphane;methyl sulfate | (1,2-dimethylimidazo[1,2-a]pyridin-4-ium-3-yl)-diphenyl-thioxo-phosphorane;methyl sulfate | CHEMBL1598051 | MLS002703110 | SMR001566915 | cid_56643192
Type:
Small organic molecule
Emp. Form.:
C21H20N2PS
Mol. Mass.:
363.435
SMILES:
Cc1c([n+]2ccccc2n1C)P(=S)(c1ccccc1)c1ccccc1
Structure:
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