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Target
Aurora kinase B
Ligand
BDBM50443492
Substrate
n/a
Meas. Tech.
ChEMBL_1275023 (CHEMBL3090781)
IC50
7.0±n/a nM
Citation
 Bavetsias, V; Faisal, A; Crumpler, S; Brown, N; Kosmopoulou, M; Joshi, A; Atrash, B; Pérez-Fuertes, Y; Schmitt, JA; Boxall, KJ; Burke, R; Sun, C; Avery, S; Bush, K; Henley, A; Raynaud, FI; Workman, P; Bayliss, R; Linardopoulos, S; Blagg, J Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. J Med Chem 56:9122-35 (2013) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50443492
Synonyms:
CHEMBL3087778
Type:
Small organic molecule
Emp. Form.:
C18H22ClN7O
Mol. Mass.:
387.867
SMILES:
CC(=O)NC[C@@H]1CCN(C1)c1c(Cl)cnc2nc([nH]c12)-c1cn(C)nc1C |r|
Structure:
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