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Target
Endothelial lipase
Ligand
BDBM50443625
Substrate
n/a
Meas. Tech.
ChEMBL_1279836 (CHEMBL3095695)
IC50
39±n/a nM
Citation
 Abdel-Magid, AF Endothelial lipase inhibitors for the treatment of atherosclerosis and cardiovascular disorders. ACS Med Chem Lett 4:1016-7 (2013) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM50443625
Synonyms:
CHEMBL3092448 | US9216998, 25
Type:
Small organic molecule
Emp. Form.:
C19H16F3NO
Mol. Mass.:
331.3316
SMILES:
FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23
Structure:
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