Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM50443627
Substrate
n/a
Meas. Tech.
ChEMBL_1279836 (CHEMBL3095695)
IC50
14±n/a nM
Citation
 Abdel-Magid, AF Endothelial lipase inhibitors for the treatment of atherosclerosis and cardiovascular disorders. ACS Med Chem Lett 4:1016-7 (2013) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM50443627
Synonyms:
CHEMBL3092450 | US9216998, 5
Type:
Small organic molecule
Emp. Form.:
C21H20F3NO
Mol. Mass.:
359.3848
SMILES:
COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Structure:
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