Reaction Details Report a problem with these data
Target
Cell division cycle 7-related protein kinase
Ligand
BDBM50443651
Substrate
n/a
Meas. Tech.
ChEMBL_1277971 (CHEMBL3095009)
IC50
140±n/a nM
Citation
 Harrington, PE; Bourbeau, MP; Fotsch, C; Frohn, M; Pickrell, AJ; Reichelt, A; Sham, K; Siegmund, AC; Bailis, JM; Bush, T; Escobar, S; Hickman, D; Heller, S; Hsieh, F; Orf, JN; Rong, M; San Miguel, T; Tan, H; Zalameda, L; Allen, JG The optimization of aminooxadiazoles as orally active inhibitors of Cdc7. Bioorg Med Chem Lett 23:6396-400 (2013) [PubMed]  Article 
Target
Name:
Cell division cycle 7-related protein kinase
Synonyms:
CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:
Protein
Mol. Mass.:
63908.16
Organism:
Homo sapiens (Human)
Description:
O00311
Residue:
574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
  
Inhibitor
Name:
BDBM50443651
Synonyms:
CHEMBL3093073
Type:
Small organic molecule
Emp. Form.:
C19H19N5O
Mol. Mass.:
333.3871
SMILES:
CC(C)[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: