Reaction Details Report a problem with these data
Target
P2X purinoceptor 1
Ligand
BDBM50444432
Substrate
n/a
Meas. Tech.
ChEMBL_1280016 (CHEMBL3096843)
IC50
267±n/a nM
Citation
 Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Design and synthesis of potent and selective P2X3 receptor antagonists derived from PPADS as potential pain modulators. Eur J Med Chem 70:811-30 (2013) [PubMed]  Article 
Target
Name:
P2X purinoceptor 1
Synonyms:
P2RX1_MOUSE | P2rx1
Type:
PROTEIN
Mol. Mass.:
44863.39
Organism:
Mus musculus
Description:
ChEMBL_1280016
Residue:
399
Sequence:
MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSGLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIMTPQQAQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLHEAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKILHPLCPVFSLGYVVRESGQDFRSLAEKGGVVGITIDWECDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGERDPAATSSTLGLQENMRTS
  
Inhibitor
Name:
BDBM50444432
Synonyms:
CHEMBL3091610
Type:
Small organic molecule
Emp. Form.:
C17H15NO7
Mol. Mass.:
345.3035
SMILES:
Cc1nc(CCc2ccc(cc2)C(O)=O)c(C(O)=O)c(C(O)=O)c1O
Structure:
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