Reaction Details Report a problem with these data
Target
Macrophage inflammatory protein-1 alpha receptor
Ligand
BDBM50444995
Substrate
n/a
Meas. Tech.
ChEMBL_1281523 (CHEMBL3102089)
IC50
>6000±n/a nM
Citation
 Hossain, N; Mensonides-Harsema, M; Cooper, ME; Eriksson, T; Ivanova, S; Bergström, L Structure activity relationships of fused bicyclic and urea derivatives of spirocyclic compounds as potent CCR1 antagonists. Bioorg Med Chem Lett 24:108-12 (2013) [PubMed]  Article 
Target
Name:
Macrophage inflammatory protein-1 alpha receptor
Synonyms:
C-C chemokine receptor type 1
Type:
PROTEIN
Mol. Mass.:
40846.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1281523
Residue:
355
Sequence:
MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFVFIIGVVGNILVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWALAILASIPALCFFKAQWEFTHHTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPNEKKAKAVRLIFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQSKQLDLAIQVTEVIAYTHCCVNPIIYVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVDQLERTSSLTPSTGEHELSGGF
  
Inhibitor
Name:
BDBM50444995
Synonyms:
CHEMBL3099954
Type:
Small organic molecule
Emp. Form.:
C23H24ClN3O5
Mol. Mass.:
457.907
SMILES:
O[C@H](COc1cccc2c1[nH]c(=O)[nH]c2=O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: