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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50445123
Substrate
n/a
Meas. Tech.
ChEMBL_1284450 (CHEMBL3106178)
Ki
7.0±n/a nM
Citation
 Burger, MT; Han, W; Lan, J; Nishiguchi, G; Bellamacina, C; Lindval, M; Atallah, G; Ding, Y; Mathur, M; McBride, C; Beans, EL; Muller, K; Tamez, V; Zhang, Y; Huh, K; Feucht, P; Zavorotinskaya, T; Dai, Y; Holash, J; Castillo, J; Langowski, J; Wang, Y; Chen, MY; Garcia, PD Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett 4:1193-7 (2013) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50445123
Synonyms:
CHEMBL3103865
Type:
Small organic molecule
Emp. Form.:
C23H23F3N6O
Mol. Mass.:
456.4635
SMILES:
N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1C(F)(F)F |r|
Structure:
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