Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50445186
Substrate
n/a
Meas. Tech.
ChEMBL_1284609 (CHEMBL3106937)
Kd
11±n/a nM
Citation
 Brune, S; Pricl, S; Wünsch, B Structure of thes1 receptor and its ligand binding site. J Med Chem 56:9809-19 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50445186
Synonyms:
CHEMBL3103202
Type:
Small organic molecule
Emp. Form.:
C24H25IN4O4
Mol. Mass.:
560.3842
SMILES:
COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2CCc1ccc(N=[N+]=[N-])c(I)c1 |r,THB:21:20:4.10.9:6.7|
Structure:
Search PDB for entries with ligand similarity: