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Target
G protein-coupled receptor 119
Ligand
BDBM50445481
Substrate
n/a
Meas. Tech.
ChEMBL_1284642 (CHEMBL3107223)
EC50
73±n/a nM
Citation
 Yu, M; Ken Zhang, J; Wang, Y; Zhu, J; Kayser, F; Medina, JC; Siegler, K; Conn, M; Shan, B; Grillo, MP; Coward, P; Jim Liu, J Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists. Bioorg Med Chem Lett 24:156-60 (2013) [PubMed]  Article 
Target
Name:
G protein-coupled receptor 119
Synonyms:
G-protein coupled receptor 119 | GPR119
Type:
PROTEIN
Mol. Mass.:
36815.88
Organism:
Macaca fascicularis
Description:
ChEMBL_107989
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKSDGVNLCFTLNLAVADTLIGVAISGLLTEQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPLRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGSCSFFAVFHPYFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRPPRTPSDFKAVRTVSVLIGSFTLSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYRQKEVRLQLYHMALGVKKALTSFLLFLSARNGGPERPRESSCHIVTISNSEFDG
  
Inhibitor
Name:
BDBM50445481
Synonyms:
CHEMBL3104879
Type:
Small organic molecule
Emp. Form.:
C23H19ClFN3O5S
Mol. Mass.:
503.93
SMILES:
CC(C)N1C(=O)c2cc(C)nc(Oc3cc(NS(=O)(=O)c4ccc(Cl)cc4)ccc3F)c2C1=O
Structure:
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