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Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Ligand
BDBM50445564
Substrate
n/a
Meas. Tech.
ChEMBL_1285688 (CHEMBL3106798)
IC50
1070±n/a nM
Citation
 Jackson, ER; San Jose, G; Brothers, RC; Edelstein, EK; Sheldon, Z; Haymond, A; Johny, C; Boshoff, HI; Couch, RD; Dowd, CS The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs. Bioorg Med Chem Lett 24:649-53 (2014) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:
DXR_MYCTU | dxr
Type:
PROTEIN
Mol. Mass.:
42846.92
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_1474510
Residue:
413
Sequence:
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
  
Inhibitor
Name:
BDBM50445564
Synonyms:
CHEMBL3103256
Type:
Small organic molecule
Emp. Form.:
C5H9NO5P
Mol. Mass.:
194.103
SMILES:
CC(=O)N(O)CC=CP(O)([O-])=O |w:6.5|
Structure:
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