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Target
Stearoyl-CoA desaturase
Ligand
BDBM50445731
Substrate
n/a
Meas. Tech.
ChEMBL_1284540 (CHEMBL3106735)
IC50
12±n/a nM
Citation
 Sun, S; Zhang, Z; Raina, V; Pokrovskaia, N; Hou, D; Namdari, R; Khakh, K; Ratkay, LG; McLaren, DG; Mork, M; Fu, J; Ferreira, S; Hubbard, B; Winther, MD; Dales, N Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects. Bioorg Med Chem Lett 24:526-31 (2014) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50445731
Synonyms:
CHEMBL3104392
Type:
Small organic molecule
Emp. Form.:
C22H23N3O3S
Mol. Mass.:
409.501
SMILES:
Cc1nc(sc1C(=O)NCc1ccccc1)-n1ccc(OCCC2CC2)cc1=O
Structure:
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