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Target
Acyl-CoA desaturase 1
Ligand
BDBM50445739
Substrate
n/a
Meas. Tech.
ChEMBL_1284539 (CHEMBL3106734)
IC50
103±n/a nM
Citation
 Sun, S; Zhang, Z; Raina, V; Pokrovskaia, N; Hou, D; Namdari, R; Khakh, K; Ratkay, LG; McLaren, DG; Mork, M; Fu, J; Ferreira, S; Hubbard, B; Winther, MD; Dales, N Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects. Bioorg Med Chem Lett 24:526-31 (2014) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50445739
Synonyms:
CHEMBL3104410
Type:
Small organic molecule
Emp. Form.:
C16H14N4O3S
Mol. Mass.:
342.372
SMILES:
Cc1nc(sc1C(=O)NCc1ccncc1)-n1ccc(O)cc1=O
Structure:
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