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Target
Complement factor D
Ligand
BDBM50446397
Substrate
n/a
Meas. Tech.
ChEMBL_1287129 (CHEMBL3111918)
IC50
2.0±n/a nM
Citation
 Abdel-Magid, AF Inhibitors of factor d may provide a treatment for age-related macular degeneration. ACS Med Chem Lett 5:106-7 (2014) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50446397
Synonyms:
CHEMBL3109655
Type:
Small organic molecule
Emp. Form.:
C21H19BrFN7O3
Mol. Mass.:
516.323
SMILES:
NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2cnc(CF)cc12 |r|
Structure:
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