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Target
Substance-K receptor
Ligand
BDBM50446427
Substrate
n/a
Meas. Tech.
ChEMBL_1287447 (CHEMBL3111742)
IC50
46000±n/a nM
Citation
 Röver, S; Andjelkovic, M; Bénardeau, A; Chaput, E; Guba, W; Hebeisen, P; Mohr, S; Nettekoven, M; Obst, U; Richter, WF; Ullmer, C; Waldmeier, P; Wright, MB 6-Alkoxy-5-aryl-3-pyridinecarboxamides, a new series of bioavailable cannabinoid receptor type 1 (CB1) antagonists including peripherally selective compounds. J Med Chem 56:9874-96 (2013) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50446427
Synonyms:
CHEMBL3109772
Type:
Small organic molecule
Emp. Form.:
C21H25ClN2O4
Mol. Mass.:
404.887
SMILES:
COCCOc1ncc(cc1-c1ccc(Cl)cc1)C(=O)N[C@@H]1CCCC[C@H]1O |r|
Structure:
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