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Target
Hepatocyte growth factor receptor
Ligand
BDBM50446591
Substrate
n/a
Meas. Tech.
ChEMBL_1290223 (CHEMBL3118144)
IC50
3.3±n/a nM
Citation
 Tang, Q; Zhang, G; Du, X; Zhu, W; Li, R; Lin, H; Li, P; Cheng, M; Gong, P; Zhao, Y Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors. Bioorg Med Chem 22:1236-49 (2014) [PubMed]  Article 
Target
Name:
Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase
Type:
Protein
Mol. Mass.:
155559.73
Organism:
Homo sapiens (Human)
Description:
P08581
Residue:
1390
Sequence:
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM50446591
Synonyms:
CHEMBL3116231
Type:
Small organic molecule
Emp. Form.:
C37H39FN6O6
Mol. Mass.:
682.7406
SMILES:
COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4c(C)cccc4C)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16,(59.77,-9.66,;61.11,-8.89,;62.44,-9.66,;63.77,-8.89,;65.1,-9.65,;66.43,-8.88,;66.42,-7.34,;67.75,-6.56,;69.08,-7.33,;70.41,-6.56,;70.4,-5.01,;69.05,-4.25,;67.73,-5.03,;66.39,-4.28,;71.73,-4.24,;73.07,-5,;74.4,-4.22,;75.74,-4.99,;75.75,-6.53,;77.07,-4.21,;78.4,-4.98,;79.72,-4.21,;79.72,-2.67,;81.06,-4.96,;81.07,-6.51,;79.74,-7.29,;78.4,-6.52,;77.07,-7.29,;77.06,-2.67,;78.39,-1.9,;75.72,-1.91,;74.39,-2.68,;73.05,-1.92,;67.77,-9.64,;67.78,-11.19,;66.44,-11.96,;65.11,-11.2,;63.77,-11.98,;62.44,-11.2,;61.1,-11.97,;59.77,-11.2,;58.44,-11.97,;57.1,-11.2,;55.77,-11.97,;54.45,-11.19,;53.12,-11.95,;53.11,-13.49,;51.77,-14.26,;54.44,-14.27,;55.78,-13.5,)|
Structure:
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