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Target
Hepatocyte growth factor receptor
Ligand
BDBM50446602
Substrate
n/a
Meas. Tech.
ChEMBL_1290223 (CHEMBL3118144)
IC50
17±n/a nM
Citation
 Tang, Q; Zhang, G; Du, X; Zhu, W; Li, R; Lin, H; Li, P; Cheng, M; Gong, P; Zhao, Y Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors. Bioorg Med Chem 22:1236-49 (2014) [PubMed]  Article 
Target
Name:
Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase
Type:
Protein
Mol. Mass.:
155559.73
Organism:
Homo sapiens (Human)
Description:
P08581
Residue:
1390
Sequence:
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM50446602
Synonyms:
CHEMBL3116220
Type:
Small organic molecule
Emp. Form.:
C36H35ClFN5O8
Mol. Mass.:
720.143
SMILES:
COc1cc(c(OC)cc1Cl)-n1c(O)c(C=Nc2ccc(Oc3ccnc4cc(OCCCN5CCCC5)c(OC)cc34)c(F)c2)c(=O)[nH]c1=O |w:15.15,(63.28,-46.33,;64.61,-45.56,;64.61,-44.02,;63.27,-43.25,;63.27,-41.71,;64.6,-40.94,;64.59,-39.4,;65.92,-38.62,;65.93,-41.7,;65.94,-43.25,;67.28,-44.01,;61.94,-40.95,;60.61,-41.72,;60.62,-43.26,;59.27,-40.95,;57.94,-41.73,;56.6,-40.97,;55.27,-41.75,;55.28,-43.29,;53.95,-44.07,;52.62,-43.3,;51.29,-44.08,;51.3,-45.62,;52.64,-46.38,;52.65,-47.92,;51.31,-48.7,;49.98,-47.93,;48.64,-48.71,;47.31,-47.94,;45.97,-48.71,;44.64,-47.94,;43.31,-48.71,;41.97,-47.94,;40.64,-48.7,;39.24,-48.09,;38.21,-49.23,;38.97,-50.57,;40.48,-50.25,;47.31,-46.4,;45.98,-45.63,;44.64,-46.4,;48.64,-45.62,;49.97,-46.39,;52.6,-41.77,;51.26,-41.01,;53.93,-40.99,;59.26,-39.42,;57.92,-38.66,;60.6,-38.64,;61.93,-39.41,;63.27,-38.64,)|
Structure:
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