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Target
Hepatocyte growth factor receptor
Ligand
BDBM50446603
Substrate
n/a
Meas. Tech.
ChEMBL_1290223 (CHEMBL3118144)
IC50
7.5±n/a nM
Citation
 Tang, Q; Zhang, G; Du, X; Zhu, W; Li, R; Lin, H; Li, P; Cheng, M; Gong, P; Zhao, Y Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors. Bioorg Med Chem 22:1236-49 (2014) [PubMed]  Article 
Target
Name:
Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase
Type:
Protein
Mol. Mass.:
155559.73
Organism:
Homo sapiens (Human)
Description:
P08581
Residue:
1390
Sequence:
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM50446603
Synonyms:
CHEMBL3116219
Type:
Small organic molecule
Emp. Form.:
C35H31F4N5O6
Mol. Mass.:
693.6442
SMILES:
COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16,(11.54,-46.54,;12.87,-45.77,;14.21,-46.54,;15.54,-45.77,;16.87,-46.53,;18.2,-45.76,;18.19,-44.22,;19.52,-43.44,;20.85,-44.21,;22.18,-43.44,;22.17,-41.9,;20.82,-41.13,;19.5,-41.91,;18.16,-41.16,;23.5,-41.12,;24.84,-41.88,;26.16,-41.1,;27.51,-41.87,;27.51,-43.41,;28.83,-41.1,;30.17,-41.86,;30.17,-43.4,;31.5,-44.17,;32.84,-43.39,;32.83,-41.84,;31.49,-41.09,;31.48,-39.55,;32.81,-38.77,;30.7,-38.2,;31.87,-38.05,;28.83,-39.56,;30.16,-38.78,;27.49,-38.79,;26.15,-39.57,;24.82,-38.8,;19.53,-46.52,;19.54,-48.07,;18.21,-48.84,;16.87,-48.08,;15.54,-48.86,;14.2,-48.09,;12.87,-48.85,;11.54,-48.08,;10.2,-48.85,;8.87,-48.08,;7.54,-48.85,;6.13,-48.23,;5.09,-49.37,;5.86,-50.71,;7.37,-50.39,)|
Structure:
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