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Target
Hepatocyte growth factor receptor
Ligand
BDBM50446605
Substrate
n/a
Meas. Tech.
ChEMBL_1290223 (CHEMBL3118144)
IC50
12±n/a nM
Citation
 Tang, Q; Zhang, G; Du, X; Zhu, W; Li, R; Lin, H; Li, P; Cheng, M; Gong, P; Zhao, Y Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors. Bioorg Med Chem 22:1236-49 (2014) [PubMed]  Article 
Target
Name:
Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase
Type:
Protein
Mol. Mass.:
155559.73
Organism:
Homo sapiens (Human)
Description:
P08581
Residue:
1390
Sequence:
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM50446605
Synonyms:
CHEMBL3116443
Type:
Small organic molecule
Emp. Form.:
C34H30F3N5O6
Mol. Mass.:
661.6271
SMILES:
COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16,(11.51,-36.53,;12.84,-35.76,;14.17,-36.53,;15.5,-35.76,;16.84,-36.53,;18.16,-35.75,;18.15,-34.21,;19.48,-33.43,;20.82,-34.2,;22.14,-33.43,;22.14,-31.89,;20.79,-31.12,;19.46,-31.9,;18.12,-31.15,;23.46,-31.1,;24.8,-31.87,;26.13,-31.09,;27.47,-31.86,;27.48,-33.4,;28.8,-31.08,;30.14,-31.85,;30.14,-33.39,;31.47,-34.15,;32.8,-33.38,;34.14,-34.14,;32.79,-31.84,;31.46,-31.07,;31.45,-29.53,;28.79,-29.54,;30.13,-28.77,;27.46,-28.78,;26.12,-29.55,;24.78,-28.79,;19.5,-36.51,;19.51,-38.06,;18.17,-38.83,;16.84,-38.07,;15.5,-38.84,;14.17,-38.08,;12.84,-38.84,;11.51,-38.07,;10.17,-38.84,;8.83,-38.07,;7.49,-38.84,;7.03,-40.31,;5.49,-40.33,;4.99,-38.88,;6.23,-37.95,)|
Structure:
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