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Target
Hepatocyte growth factor receptor
Ligand
BDBM50446617
Substrate
n/a
Meas. Tech.
ChEMBL_1290223 (CHEMBL3118144)
IC50
28±n/a nM
Citation
 Tang, Q; Zhang, G; Du, X; Zhu, W; Li, R; Lin, H; Li, P; Cheng, M; Gong, P; Zhao, Y Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors. Bioorg Med Chem 22:1236-49 (2014) [PubMed]  Article 
Target
Name:
Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase
Type:
Protein
Mol. Mass.:
155559.73
Organism:
Homo sapiens (Human)
Description:
P08581
Residue:
1390
Sequence:
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM50446617
Synonyms:
CHEMBL3116241
Type:
Small organic molecule
Emp. Form.:
C37H37ClFN5O8
Mol. Mass.:
734.17
SMILES:
COc1cc(c(OC)cc1Cl)-n1c(O)c(C=Nc2ccc(Oc3ccnc4cc(OCCCN5CCCCC5)c(OC)cc34)c(F)c2)c(=O)[nH]c1=O |w:15.15,(62.8,-43.66,;64.13,-42.89,;64.13,-41.35,;62.8,-40.59,;62.79,-39.04,;64.12,-38.27,;64.11,-36.73,;65.44,-35.95,;65.45,-39.03,;65.46,-40.58,;66.8,-41.34,;61.46,-38.28,;60.13,-39.05,;60.14,-40.59,;58.79,-38.28,;57.46,-39.06,;56.12,-38.3,;54.8,-39.08,;54.8,-40.62,;53.47,-41.4,;52.15,-40.63,;50.82,-41.41,;50.82,-42.95,;52.16,-43.71,;52.17,-45.26,;50.83,-46.03,;49.5,-45.26,;48.17,-46.04,;46.83,-45.27,;45.5,-46.04,;44.16,-45.27,;42.83,-46.04,;41.5,-45.27,;40.16,-46.03,;38.84,-45.26,;37.51,-46.02,;37.5,-47.56,;38.83,-48.33,;40.18,-47.57,;46.83,-43.73,;45.5,-42.96,;44.17,-43.73,;48.16,-42.95,;49.5,-43.72,;52.13,-39.1,;50.78,-38.34,;53.45,-38.32,;58.78,-36.75,;57.44,-35.99,;60.12,-35.97,;61.46,-36.74,;62.79,-35.97,)|
Structure:
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