Reaction Details Report a problem with these data
Target
Enoyl-acyl carrier reductase ENR
Ligand
BDBM50392117
Substrate
n/a
Meas. Tech.
ChEMBL_1290812 (CHEMBL3118190)
IC50
>1000±n/a nM
Citation
 Wilkinson, C; McPhillie, MJ; Zhou, Y; Woods, S; Afanador, GA; Rawson, S; Khaliq, F; Prigge, ST; Roberts, CW; Rice, DW; McLeod, R; Fishwick, CW; Muench, SP The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target. Bioorg Med Chem Lett 24:911-6 (2014) [PubMed]  Article 
Target
Name:
Enoyl-acyl carrier reductase ENR
Synonyms:
Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative
Type:
PROTEIN
Mol. Mass.:
43663.67
Organism:
Toxoplasma gondii
Description:
ChEMBL_1290812
Residue:
417
Sequence:
MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSSSSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKAALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLRRDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
  
Inhibitor
Name:
BDBM50392117
Synonyms:
CHEMBL1945507
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N2
Mol. Mass.:
305.202
SMILES:
Cc1cc2ncn(Cc3ccc(Cl)c(Cl)c3)c2cc1C
Structure:
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