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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50447562
Substrate
n/a
Meas. Tech.
ChEMBL_1289424 (CHEMBL3116920)
Kd
481000±n/a nM
Citation
 Dragovich, PS; Zhao, G; Baumeister, T; Bravo, B; Giannetti, AM; Ho, YC; Hua, R; Li, G; Liang, X; Ma, X; O'Brien, T; Oh, A; Skelton, NJ; Wang, C; Wang, W; Wang, Y; Xiao, Y; Yuen, PW; Zak, M; Zhao, Q; Zheng, X Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 24:954-62 (2014) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50447562
Synonyms:
CHEMBL3112704
Type:
Small organic molecule
Emp. Form.:
C12H14N4O
Mol. Mass.:
230.2658
SMILES:
CCc1cc(C(=O)Nc2cccnc2)n(C)n1
Structure:
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