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Target
N-arachidonyl glycine receptor
Ligand
BDBM50448074
Substrate
n/a
Meas. Tech.
ChEMBL_1292268 (CHEMBL3124699)
IC50
>10000±n/a nM
Citation
 Harms, H; Rempel, V; Kehraus, S; Kaiser, M; Hufendiek, P; Müller, CE; König, GM Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. J Nat Prod 77:673-7 (2014) [PubMed]  Article 
Target
Name:
N-arachidonyl glycine receptor
Synonyms:
G-protein coupled receptor 18 | GPCRW | GPR18 | GPR18_HUMAN | NAGly receptor
Type:
PROTEIN
Mol. Mass.:
38150.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107601
Residue:
331
Sequence:
MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
  
Inhibitor
Name:
BDBM50448074
Synonyms:
Emindole Sb
Type:
Small organic molecule
Emp. Form.:
C28H39NO
Mol. Mass.:
405.6154
SMILES:
CC(C)=CCC[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@]21C |r,wU:12.12,6.6,8.8,14.15,wD:17.18,28.33,6.5,(7.26,-25.92,;7.27,-24.39,;8.61,-23.64,;5.95,-23.62,;5.97,-22.09,;4.62,-21.3,;3.28,-22.08,;3.27,-20.55,;3.27,-23.63,;4.61,-24.41,;1.92,-24.4,;.59,-23.61,;.6,-22.07,;.59,-20.54,;1.94,-21.31,;1.95,-19.76,;.6,-18.98,;-.73,-19.75,;-2.2,-19.27,;-3.1,-20.54,;-2.21,-21.78,;-3.12,-23.02,;-4.58,-22.54,;-5.91,-23.31,;-7.23,-22.54,;-7.23,-21.01,;-5.91,-20.24,;-4.58,-21,;-.73,-21.3,;-.75,-22.83,)|
Structure:
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